Top similar games like Deck of Defense:

Cubic Cosmos is a thrilling fast-paced roguelike card game. You have been trapped in a deadly game. One wrong move could see you reduced to a plaything of the goddess. Can you free yourself from the endless cycle and escape your fate?

Tower defense meets deck building in Deck Defense. Defending against the blobs is no easy feat. Will you prioritise fortifying your tower defenses or expanding the map? Build your deck with over 75 cards to choose from.

"Plants vs. Animals" is a TD game where players, as plant summoners, collect and upgrade plant cards against animal waves. Victories yield new cards and genetic materials for card mutation and enhancement.Strategic card play and evolution are key

Combine tactics and strategy in this roguelike deckbuilder, where you must build your deck, train and evolve your team. Step into a mystical world where the Genkai battle in a quest for power and harmony, and prepare for the imminent arrival of the Primal Genkai.

Arbiters Dream is a singleplayer roguelike deckbuilder with tower defense combat that isn't only about building defense, but is rather a duel where you also have to launch attacks against the enemies base. Shape your deck, banish the Chaos Rifts and protect a young universe.

Krumit's Tale, the second game in the Meteorfall universe, is a new take on the deckbuilding roguelike genre. Use your cards to clear dungeons, then upgrade your deck with new cards and perks to press forward. The fate of the world is in your hands.

Nobody wants to throw a boring party. Wedding Planic! is a roguelike, deck builder about managing a wild wedding plan. Arrange a deck of neurotic guests, set wedding favours and create synergies with surprising and sometimes explosive results.

Spliced is a hybrid roguelite deck-builder. Play as a symbiotic ooze, taking the parts and abilities of enemies you defeat. Use cards to battle enemies and navigate the environment.

In this turn-based roguelike deck-building game, you must recruit troops and use artifacts to repel the gnoll army until help arrives. Every new day the story unfolds, revealing new threats but also surprises. Roll the dice and command your troops to protect the kingdom!

Realm of Advent is an endless eerie loop of Roguelike deckbuilding strategy. In this addictive card game, craft your unique deck, launch auto-battles with one tap, and unleash insane chain reactions from over 300 cards and relics to conquer mighty Apostle bosses!

A cute yet brutal tactical deckbuilder: Command your Squad and outsmart unique encounters to ultimately Meet the Master.

Now fully rebuilt and remastered, Guild of Dungeoneering Ultimate Edition is a turn-based dungeon crawler with a twist: instead of controlling the hero you build the dungeon around them.

Portal of Defense is a strategy Roguelike tower defense game. The game can complete all operations by simply dragging and dropping with the mouse. Explore the portal and obtain powerful items to become stronger and resist the tide of enemy attacks.

Tavern Defense is a Tower Defense + Roguelike Deckbuilder game where you build your deck of cards, carve your own paths for monsters, and create magnificent synergies to win the game.

Click to roll the crystal ball across the table, dodging obstacles and facing bosses while building a deck of cards that completely changes your strategy with every run. Help Mewlin, a very curious orange cat, make a total mess in this magical clicker with deckbuilding elements.

A whimsical roguelike deckbuilder with rich card interactions and deep synergies. Strategize through perilous space missions by assembling powerful crewmates and gadgets. Can you beat your objectives before time runs out?

Dog Witch is a roguelike deckbuilder where your spells are fueled by enchanted dice. Combine over 150 unique items to forge ever-evolving strategies, perfect synergy combos, summon minions, and tackle an endless range of foes so bizarre, they’ll leave your tail wagging in disbelief!

Party Demon is a tower defense, deck-building game where your main goal is to protect a Lady Demon’s birthday party from human intruders. Build your castle on a budget and defend it in real-time with a deadly Trap Deck full of demonic weapons.

You make the cards! Use your wits and curiosity to build a deck ready to take on the Skeleton Crew and their waves of baddies!

We fused card games and roguelikes together to make the best single player deckbuilder we could. Craft a unique deck, encounter bizarre creatures, discover relics of immense power, and Slay the Spire!

Tower Knight is a deck-building & tower defense strategy game. Build your deck to strengthen your position, level up your knight, and win by capturing enemy towers.

A Pachinko Roguelite where you shoot musical balls at problem-shaped enemies that won’t let musician monks meditate. Collect relics and scenario pieces, build synergies, and place them to construct the battlefield itself.

A steampunk deckbuilder tower defence roguelike. Draft cards to build towers, cast spells, and rebuild a shattered sky-city, one crashed fragment at a time, while the swarm closes in.

Tower Deckfense is an exciting blend of tower defense and deck building. Build your deck strategically, upgrade your towers, and equip them with powerful modifiers to discover the best combinations and devastate your enemies.

Carefully craft your Mosaic in this fantasy themed deckbuilding game. Battle by battle, tile by tile, you'll form synergies and build up your Mosaic's combo potential, hoping to beat the curve as you forge deeper into enemy territory.

Balatro Meets Blackjack with a Cuphead aesthetic in this casino rogue-lite where you gamble with your abilities. Every chip you bet can turn the tide in your favor, but you could also lose it all in a bad hand. Think you can beat the house? 

Defend The Wall on a tactical 11x7 grid. Master the art of Duoshifting: play a card to shift between your two battle vehicles. Outmaneuver waves of scavenged war machines, unleash game-breaking hacks and chain synergies. Draft, fight, and survive in this endlessly replayable tactical roguelite.

A chance-based roguelike deckbuilder with silly, chaotic dragons. Spin the roulette wheel to multiply your card effects, manipulate the odds, and unleash ridiculous combo turns. Build a synergistic deck, outsmart RNG, and climb your way to the Boss Dragons.

Build the ultimate Zoo in this number-go-up roguelike deckbuilder. Find powerful mythical animals, boost them with snacks, and even manipulate the board itself. Break the game by scoring millions (and more) with insane combos.

Sail through pirate-infested waters in this unconventional roguelike deckbuilder. Collect ingredients, craft your own sushi cards, and feed them to hungry pirates in tactical turn-based encounters. Combine active, passive, and reactive abilities to satisfy unruly customers and maximize profits.

A deckbuilding card game. Summon minions, sacrifice wounded ones to summon stronger minions, use their effects to grow fast, and defeat your opponent within a set number of turns. Keep upgrading your minions, discover Treasures, build unique decks, and aim to reach the top of Diamond Town!

Build twisting mazes with tetromino blocks and deploy unique towers in this strategic roguelite tower defense adventure!

A roguelite deckbuilding adventure game about magical coins. You play as a lootmancer, who can unlock the hidden power inside of coins and use them in magical duels. The loots you take from chests and enemies also become your next moves, so plan carefully!

ArtifactHunt: Yao is a roguelike strategy deck-building game focused on multiplicative numerical growth. Form specific combinations with Souls, defeat enemies, collect more souls, seek out powerful artifacts, craft your very own unique build. Embark on an adventure filled with endless possibilities!

Grid management roguelike tower defense that emphasizes mechanics and features dazzling visual effects. Don't overthink it, just stack and play! Enhancement modules boost your attributes, affix modules change the mechanics, and more... all within the grid. Time to create a new and improved build!

Click Them Off is a hand-drawn roguelike deckbuilder. Conquer a strict hand limit by refreshing the store to stack identical cards, fusing them into unstoppable power. When nasty humans invade to steal your resources, wield three unique weapons to click them off!