Top similar games like Protolife:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

The ultimate mash-up of Real-time Strategy and Tower Defense!

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

After the destruction of the EARTH in 2150, the leaders of the Eurasian Dynasty escaped on board an evacuation fleet. Now they are fighting for the survival of the human species. Their base is one large building comprising of smaller variable parts.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Fight for control of a frontier world. Gather resources, build your base, and command your forces in battle. Survive long enough to unleash your ultimate weapon - THE EPIC.

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Build defenses to protect your mining sites from the hostile native alien species. Explore the planet and discover the true reasons you've been sent here for. A true old school pixel-art experience.

{{An RTS inspired by the classics of the past!}} Making up for it's subpar retro graphics with fun gameplay and modern multi-threaded tech enabling huge battles to run smooth... Featuring singleplayer challenges, skirmish, sandbox, 10-player multiplayer & workshop modding.

Be the ultimate CEO and military strategist in this genre fusion of strategy and business management. Create your own company, hire employees, research weapon technology, and take control of units on the battlefield to defend the moon against an alien invasion. Aliens down, profits up!

Terminal squad: swarmites is a game with indirect control where you must erect a chain of buildings, which generate resources for construction or the combat units for destruction of an enemy.

Doomsday clock ticks 5 minutes to midnight, unravel the tale of a nuclear disaster's genesis. Dive into chaos blending humor and horror, setting the stage for strategic battles. Crafted by a dedicated team, this prologue teases the reborn classic RTS with laughs and chills!

Cosmic Stronghold is a mix of the genres RTS and Tower Defense. Your primary goal is to keep your space station alive for as long as possible, so that it can harvest the nearby mines for precious mineral ores. You will be faced with waves of enemies, getting stronger and stronger for each wave.

Setting the bar as the definitive tower defense game, Defense Grid 2 introduces new worlds and threats to test your tower placement strategies. With a bold new look and the addition of new game modes, player-versus-player and multiplayer co-op, every play brings fun new opportunities and challenges.

An exciting sci-fi real-time strategy game. You are the leader of a band of elite Marines on a rescue mission; it is your job to secure the outpost and rescue lost miners. Aliens are running amok; it won't be easy...

STARGEARS is a sci-fi RTS set on an alien world.

The year is 2047. A massive nuclear fireball explodes high in the night sky, marking the dramatic beginning of the Third Tiberium War and the long-awaited return of the most groundbreaking Real-Time Strategy franchise of all time

Star Trek: Prelude is a space-based game that builds defense towers on earth to defend against alien invaders called Black Ember.

Lead an armored squad through the perils of this reversed tower defense action-strategy game!

"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"

Halo Wars: Definitive Edition is an enhanced version of the real-time strategy classic, Halo Wars, updated to run natively on PC. Halo Wars: Definitive Edition includes improved graphics, new achievements and all of the DLC created for the landmark real-time strategy game.

Command a team of 5 elite soldiers against an alien horde of 100,000. Surrounded on all sides, you must outmaneuver and outsmart the enemy.

You are isolated on a small meteor and need to build a fire to escape before being destroyed by aliens. Use your limited space to create machines and obtain more and more resources. Enjoy this mix of puzzles, tower defense and incremental gameplay.

Ifectra is a strategy game set in 2124 on the distant planet Emevera III, ruled by the Maxploit Corporation, where an epidemic of a yet unknown virus broke out. Your goal as the corporation security commander is to evacuate as many healthy people as possible and to eliminate infected individuals.

Sci-fi Tower Defense real-time strategy with pleasant adaptive music. Play as a commander of a space station which got stuck in a time anomaly.

The Mission Exorcist is a game that combines elements of Tower Defense and Open World genres. Players take on the role of an Exorcist tasked with protecting a dimensional door that connects Hell and the human world for 15 days. The game's end will depend on the player's remaining Life Force level.

HEX Defense is a tower-based strategy game set in a hexagonal world where you have to fight enemy forces by combining simple blocks into complex tower patterns.