Top similar games like Protolife:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

The ultimate mash-up of Real-time Strategy and Tower Defense!

Power the Unknown is a strategy game where you build a base on an unexplored planet and defend it from swarms of hostile bugs. Mine resources and generate enough energy to power your ever-growing base.

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

Von Neumann Project is about a self replicating probe as it charts the galaxies, peacefully of course. Mine, build, expand, and explore in this sci-fi RTS. Remember to have as little impact on your surroundings as possible and protect yourself at all costs.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Rise of the Cones is a tower defense game where a relentless army of cones is marching toward your base. They will not stop. Build towers, shape them with branching upgrades, and figure out how to hold the line.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

After the destruction of the EARTH in 2150, the leaders of the Eurasian Dynasty escaped on board an evacuation fleet. Now they are fighting for the survival of the human species. Their base is one large building comprising of smaller variable parts.

Survive endless waves of dark entities, use your clicks as a resource, and grow stronger with every run. Find and upgrade powerful modules and unlock new technologies in this incremental clicker defense game. Also - Everything is square.

Build the supply lines that keep your guns firing. Feed the Front is a sci-fi RTS where resources and ammunition fly between buildings. Mine small planets, automate logistics, and defend your expanding base against rival commanders and alien bugs.

Free-form space defense in real time. Mine asteroids, route power from Helios and hold off pirate fleets. Lose one Conductor and a whole flank goes dark. Build without a grid, choose your weapons and take on 21 levels.

Fight for control of a frontier world. Gather resources, build your base, and command your forces in battle. Survive long enough to unleash your ultimate weapon - THE EPIC.

Defense Grid: The Awakening is a unique spin on tower defense gameplay that will appeal to players of all skill levels. A horde of enemies is invading, and it's up to the player to stop them by strategically building fortification towers around their base.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Drop Order is a dark sci-fi tactical tower defense where every turret placement shapes both your firepower and the enemy's route. Build synergistic defenses, create deadly mazes, and survive alien hordes with cards and hands-on drone combat.

Equip your mechs, drop them from orbit and hold the line. NEEDLEFALL is a horde defense RTS for 1–4 players. Build pipes to carry Flux to the Core and your turrets, raise walls, command your mechs against swarms of hundreds of creatures and destroy the twelve hives.

Build and defend a space colony where every unit of power and every crew assignment matters. Expand production, research new technologies, shape the battlefield with walls and weapons, and adapt your strategy against alien swarms across nine campaign operations.

Xenogarden is a dark sci-fi strategy game where you spread an alien swarm, build synapse nodes, defend your core, and overwhelm human defenders before they destroy your living network and cut the invasion apart.

Hold a mining outpost on an alien world while thousands of insects pour through the rock tunnels like a flood. Place towers on the high ground, aim their firing arcs, and spend the biomass from every run, won or lost, on upgrades that let you hold a little longer next time.

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

{{An RTS inspired by the classics of the past!}} Making up for it's subpar retro graphics with fun gameplay and modern multi-threaded tech enabling huge battles to run smooth... Featuring singleplayer challenges, skirmish, sandbox, 10-player multiplayer & workshop modding.

Terminal squad: swarmites is a game with indirect control where you must erect a chain of buildings, which generate resources for construction or the combat units for destruction of an enemy.

Be the ultimate CEO and military strategist in this genre fusion of strategy and business management. Create your own company, hire employees, research weapon technology, and take control of units on the battlefield to defend the moon against an alien invasion. Aliens down, profits up!

Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.

A strategic and action-packed base survival game where you mine crystals, build units, and defend your base against waves of UFOs. Defeat enemies, gather resources, and unlock new planets to expand your defenses. Are you ready to conquer the galaxy?

A sci-fi tower defense in the spirit of classic RTS games. Fly an armed drone over alien battlefields, build and upgrade turrets, unleash superweapons and find out why the terraformer robots rebelled — before your crew is lost on an unknown planet.

Defend a lone Core against waves from every direction. Collect the scrap enemies leave behind, build production chains and automated turrets, then carry your upgrades into the next, harder chapter. A sci-fi base-defense campaign across 4 acts, plus prequel and skirmish modes.

Star Pulse: The War is an independent real-time strategy game that merges science fiction with fantasy. Players will command a sci-fi faction, harnessing the power of star pulse to gather resources, construct buildings, train troops, and nurture heroes in the fight against invading magical forces.

Atom Assault throws you into a chaotic Red vs Blue war where everything explodes, infantry fish for money, and you can even pilot nukes in first person. Full 3D, fully destructible world, fast, funny, proudly indie. If you miss old school RTS mayhem, this one hits hard.

A pixelated 2.5D RTS meets tower defense as you battle mutated ants in a short campaign. Build walls, place turrets, and hold the line to reclaim Earth's surface in this tactical fight for survival where placement of everything matters.