Top similar games like Protolife:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

The ultimate mash-up of Real-time Strategy and Tower Defense!

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

Von Neumann Project is about a self replicating probe as it charts the galaxies, peacefully of course. Mine, build, expand, and explore in this sci-fi RTS. Remember to have as little impact on your surroundings as possible and protect yourself at all costs.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?

Rise of the Cones is a tower defense game where a relentless army of cones is marching toward your base. They will not stop. Build towers, shape them with branching upgrades, and figure out how to hold the line.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

After the destruction of the EARTH in 2150, the leaders of the Eurasian Dynasty escaped on board an evacuation fleet. Now they are fighting for the survival of the human species. Their base is one large building comprising of smaller variable parts.

Fight for control of a frontier world. Gather resources, build your base, and command your forces in battle. Survive long enough to unleash your ultimate weapon - THE EPIC.

Defense Grid: The Awakening is a unique spin on tower defense gameplay that will appeal to players of all skill levels. A horde of enemies is invading, and it's up to the player to stop them by strategically building fortification towers around their base.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Drop Order is a dark sci-fi tactical tower defense where every turret placement shapes both your firepower and the enemy's route. Build synergistic defenses, create deadly mazes, and survive alien hordes with cards and hands-on drone combat.

Build and defend a space colony where every unit of power and every crew assignment matters. Expand production, research new technologies, shape the battlefield with walls and weapons, and adapt your strategy against alien swarms across nine campaign operations.

Xenogarden is a dark sci-fi strategy game where you spread an alien swarm, build synapse nodes, defend your core, and overwhelm human defenders before they destroy your living network and cut the invasion apart.

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

{{An RTS inspired by the classics of the past!}} Making up for it's subpar retro graphics with fun gameplay and modern multi-threaded tech enabling huge battles to run smooth... Featuring singleplayer challenges, skirmish, sandbox, 10-player multiplayer & workshop modding.

Terminal squad: swarmites is a game with indirect control where you must erect a chain of buildings, which generate resources for construction or the combat units for destruction of an enemy.

Be the ultimate CEO and military strategist in this genre fusion of strategy and business management. Create your own company, hire employees, research weapon technology, and take control of units on the battlefield to defend the moon against an alien invasion. Aliens down, profits up!

Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.

A strategic and action-packed base survival game where you mine crystals, build units, and defend your base against waves of UFOs. Defeat enemies, gather resources, and unlock new planets to expand your defenses. Are you ready to conquer the galaxy?

Star Pulse: The War is an independent real-time strategy game that merges science fiction with fantasy. Players will command a sci-fi faction, harnessing the power of star pulse to gather resources, construct buildings, train troops, and nurture heroes in the fight against invading magical forces.

Atom Assault throws you into a chaotic Red vs Blue war where everything explodes, infantry fish for money, and you can even pilot nukes in first person. Full 3D, fully destructible world, fast, funny, proudly indie. If you miss old school RTS mayhem, this one hits hard.

A pixelated 2.5D RTS meets tower defense as you battle mutated ants in a short campaign. Build walls, place turrets, and hold the line to reclaim Earth's surface in this tactical fight for survival where placement of everything matters.

Cosmic Stronghold is a mix of the genres RTS and Tower Defense. Your primary goal is to keep your space station alive for as long as possible, so that it can harvest the nearby mines for precious mineral ores. You will be faced with waves of enemies, getting stronger and stronger for each wave.

A hand-drawn survival tower defense on a hostile alien world. No fixed lanes — towers and ice walls reshape the swarm in real time. Command distinct frontline heroes, trigger ecological chain reactions, and defend the Purification Core across expanding battlefields.

TINAD is a unique tower defense game where you defend your retirement home from overeager heroes. Play as the dungeon itself. Deploy traps, summon minions, and prove you’re just trying to enjoy your golden years in peace against heroes who can’t read the sign and assume every dungeon is evil.

Dust Front is a classic RTS with grand strategy elements and a non-linear campaign. Lead strategic maneuvers, overwhelm your enemies with cannon fodder, or stomp them into the stone age with carpet bombing on the lifeless fields of Dust Front.

Raise a fallen keep by day, and hold it through the dark. Villagers with names and tempers fell timber and work the fields — then take up spears when night comes. A dark fantasy settlement-builder defense game.

An exciting sci-fi real-time strategy game. You are the leader of a band of elite Marines on a rescue mission; it is your job to secure the outpost and rescue lost miners. Aliens are running amok; it won't be easy...

RTS - Tower Defense - MOBA - Hybrid in a post-apocalyptic world overrun by anomalies. Build a base. Defend your perimeter. Defeat your opponents.