Top similar games like PHYSARUM: Slime Mold Simulator:

Create and destroy on a scale you’ve never imagined!

The Sapling is a short simulation game where you design your own plants and animals, and put them in a world together. Or you turn on random mutations, and see what evolution does to your ecosystem!

Create & destroy on an unimaginable scale with a realistic physics-based space simulator. Explore the beauty of our universe and the fragility of our planet. Use science to bend the laws of gravity, collide planets, boil away oceans, fire epic space lasers, and customize your universe. VR optional.

Dynamic abstract sandbox universe. Changes and evolves as you do.

Seed, Breed, Create. From single cell organisms to complex ecosystems. Evolve every part of your own unique aquarium / terrarium by applying scientifically accurate principles of natural and artificial selection, in Creatura - ultimate Virtual Evolution Vivarium Simulator.

Space Simulator and Music Machine!

Eureka! Superconductor Lab is a crafting+simulation game where you synthesize materials and witness the astonishing scientific phenomena. Work alongside scholars, science geeks, and your girlfriend to synthesize the Holy Grail of modern physics: a room-temperature superconductor!

Graviton is a falling sand simulator in which you define your own interactive sand art. Sit back, relax, and draw from existing sand materials. Or take time to learn and create your own sands with complex rules. The possibilities are endless!

The world's first science-based photorealistic interactive 3D planetarium that models the entire Universe, using procedural generation for uncharted areas.

This is a beautiful "Idle", "Incremental" game based on spirals and mathematics. Your goal is to make the spiral grow farther and farther from the origin. The game is very simple, but it is very deep and can be enjoyed for a long time!

An evolution simulation game. Take control of your species in the environment and edit your species as a whole. Compete with other evolving species for resources on an alien planet.

Customize your own ant colony. Test its viability against starvation and predation. Pit rival colonies against each other and see who comes out on top. Do you like to watch ants go about their day?

Protect the environment, and save it from harm! Give commands to the animals, observe their rituals and help them survive. Face different disasters, react to human presence and help the animal kingdom flourish in this unique, environmental experience!

A toy ecosystem with fully simulated genetics and evolution. Will you tinker with DNA or sit back, relax, and see if life finds a way?

Vilmonic is an artificial life simulator and genetics and evolution sandbox game. Protect and breed unique pixel-art life forms where pixels and color have meaning. Craft tools and buildings and change the environment. Find ancient tech and fend off haywire zombitons. Craft Farm Breed Evolve!

PolyPine is a cozy forest simulation game where you create habitats for plants, insects and animals, and click on animals to make them poop! Start with a few basic seeds and attempt to grow a thriving ecosystem.

The Magic Kaleidoscope is an amazing anti-stress coloring game where you can become the creator of your own magical textures and animations.

Are you looking for something completely different? An oddity? An enigma? Or perhaps .. an Anomaly? Anomalies may be a game, then again it may not. One user described it as "A million musical leeches, waiting to suck the serotonin from my brain." And that's just the beginning...

Be the Universe in this epic, award-winning reality simulation game - featuring thousands of playable characters, endless exploration, an extraordinary soundtrack and narration from Alan Watts.

Guide the evolution of virtual lifeforms that learn to move in a world based on realistic physics. This world already features built-in mechanisms like heredity and natural selection. The player takes on the role of a creator, manipulating these natural processes to help lifeforms learn and evolve.

You play as a scientist who is shrinking every second in a race against time! Find all the ingredients and formulas scattered around the laboratory, which are necessary for producing the life-saving antidote. But beware, your time is very precious.

Play with evolution! Species: ALRE is a scientifically-grounded, emergent simulation of natural selection. Creatures evolve and speciate in response to in-game mutation and selection forces, allowing you to experience and tinker with evolution in real-time.

Manipulate climate, add plants and evolve creatures in this planet and life sandbox simulation game. From cells to civilisations, spread life throughout the whole planet. Or just enjoy watching your creation burn!

The epic story of evolution, technology, humanity, and dinosaurs is yours to tap.

Create and evolve your own digital lifeforms! Watch or interact as your creations adapt and thrive in a world governed by the laws of physics. Download now and start your own evolutionary journey!

Build the most advanced operating system ever created! Can you master the fictional simulation language of this mind-bending machine? Design circuits, automate UBITS (coloured mobile data blocks), and optimize your system. The Admin is always watching, and he’s not what he seems.

Click to place components to create anything from a piano to a computer in a virtual sandbox environment.

Explore real digital life in The Bibites! Play god as you guide your bibites on their evolutionary journey. Analyze their Neural Network brains and genetic information as they adapt to their environments. Save your favorites and test their strength in Challenge Mode!

A calm creative experience where you guide the development of an alien ecosystem. Study the environment and discover what drives it, or just sit back, relax, and see what happens!

Satellite Command is a realistic, relaxing astrophysics simulator. Complete contracts with real data, launch and take control of ever more powerful Satellites, research advanced technology and build your Space Agency!

Have you ever wondered what the whole Universe looks like? With the myriad Galaxies, each containing billions of Stars, including our Solar System? Have you seen a Human Brain and its Neurons? DNA? What about the Electrons surrounding the tiny Atomic Nucleus? And what lies at even smaller scales?

Conductor is an audiovisual experience creation engine that encourages you to craft, save, and share funky environments with its vibrantly creative tool-set alongside all of your favorite media.

EcoGenesis is a 2D black-box ecosystem simulator where you need to craft an ecosystem that can withstand the test of time. You must unlock creatures and balance your environment while driving towards one of the three victory conditions in this turn-based simulation.

Strategy game about genes and animal species. Evolve, reproduce, expand to new territories, survive, and fight to achieve various goals like biodiversity or dominance in the ecosystem.

Build your dreams in this polyrhythm designer. Dream Gen is all about crafting relaxing or chaotic melodies, which can be played out for hours on end.